While most RPGs revolve around saving the world from certain destruction, World Destruction tries the opposite. In a world (you knew that was coming) where humans serve as livestock for the ruling beastmen, and where sand fills the roles of water and fire, you play as Kyrie, a young lad who is recruited by the "World Destruction Committee" to assist in putting an end to their world. As it turns out, Kyrie alone holds the power needed to do it.
Kyrie will be joined by heroine Morte, as well as four more characters introduced in Famitsu: Naja, a half-human, half-beastman fighting on behalf of the world; Agan, a comical member of a pro-human guerrilla organization; Li?a, a 300-year-old dragonkin trapped in a 16-year-old body; and Toppy, a badass, bounty-hunting bear who sports an eye patch.