* When the player talks to Rose in Metal Gear Solid 4, they can shake their controller to see her breasts jiggle. Two characters: Amanda and Cécile (also Strangelove) has a feature called "Model Viewer." This will show the player a 3D view of the character and if they move the analog stick, their breasts will jiggle. Also, the player can have the female characters pose in bathing suits in the Model Viewer.
* While searching through the trucks, the player can come across the following things: Hideo Kojima will be in one of the trucks and Snake will say "Director!" ("Mr. Kojima!" in the english version) Another one will have gears for a vehicles and Snake says "Metal....gears." One truck has a poster of Mei Ling during Metal Gear Solid. The last one has numerous plushes of Solar Boy Django's sunflower-like companion, Master Otenko from the Boktai series (at which Snake will yell "SUNLIGHT!")
* In a briefing file with Cecile, Kaz will talk about adding Kojima to her name which will be: Cecile Kojima Caminades. In Japanese, Caminades can also be translated into "I am God" or Kojima is god. She's named after a real person, Cecile Caminades, who is in charge of press relations at Konami France.[14]
* The player can obtain a soldier that is Hideo Kojima. His profile says "My body is made up from 70% movies, the extra 30% is up to you."
* In Extra Ops, there is a mission where the player can date with Paz. During that mission, if the player has the love box, they can invite her into the box (actually, using the Love Box is required for completing the mission). If the player does the mission while wearing the naked uniform, Paz will become embarrassed and will run away from them. If the player beats this mission with a S rank, the next time they do the mission, Paz will be in her underwear. Similarily, there is also an Extra Ops mission where Big Boss dates Kaz, and has similar methods to completing the mission as well as similar results with a S rank.
* In the Interactive cutscene where Amanda is being caught by the kidnapper, the player can shoot Amanda instead, Snake will miss and she will curse him.
* Looking at soldier's profiles can be very interesting as there are random things. One of the soldier says "I have a friend named Johnny, do you know him?" which probably means Johnny from Metal Gear Solid 3. Another had said "If I make a girlfriend one day, I would like to go in a cardboard box with her." Another one talks about Santa.
* Unlock Extra Ops 63, 64 and 65 then you will get to play the game Pooyan. The player will have to shoot all the fultoned soldiers that appears. Pooyan is a well known NES game.
* Metal Gear Mk. II made an appearance in the cutscene between Big Boss and Huey after the Pupa battle.
* When the player shoots a soldier with Tanegashima, a tornado will shoot up the soldier into the air and Miller will call them and say "There's a soldier hanging on the helicopter."
* When you shoot a soldier directly in the rear end with a Mk.22 (any rank), he'll be knocked out (he will also cry out "Ah!").